Sejal Saglani BSc(hons) MBBS MD FRCPCH Professor of Paediatric Respiratory Medicine & Director, Centre for Paediatrics & Child Health, Imperial College London Honorary Consultant, Royal Brompton Hospital, London My research focusses on mechanisms underlying the inception of severe asthma and preschool wheeze in children, finding novel therapies to improve control, reduce exacerbations and to achieve disease modification. Combined investigations using my neonatal mouse model, paediatric bronchoscopic airway samples, and translation to clinical trials has led to a research programme with the ultimate aim of identifying disease modifying therapies for preschool wheeze and childhood severe asthma.